{"product_id":"core-nutritionals-hair-skin-nails","title":"Core Nutritionals | Hair Skin Nails | 150 Capsules","description":"\u003ch2\u003eTrademarked beauty actives, full transparency, real hydration and barrier support.\u003c\/h2\u003e\n\u003cp\u003eCore Nutritionals Hair, Skin, \u0026amp; Nails is not a trendy “beauty blend.” It is a fully disclosed, capsule-based nutricosmetic formula built around four real goals: improve skin hydration, support collagen and extracellular matrix integrity, defend against oxidative stress that accelerates visible aging, and provide foundational support for stronger hair and nails. That strategy matters, because most products in this category lean too heavily on biotin alone. Core instead uses biotin as a supporting player and builds the formula around trademarked ingredients and meaningful doses.\u003c\/p\u003e\n\u003cp\u003eBiotin is included at 5,000mcg, which is above the commonly cited 2.5mg supplemental range. Biotin is an essential cofactor for carboxylase enzymes involved in fatty acid synthesis, gluconeogenesis, and amino acid metabolism, and it also influences gene regulation through histone biotinylation. It is popular in the category, but the honest formulation take is this: evidence for visible hair and nail benefits in healthy, non-deficient users is limited. Core still includes it at a robust dose, but does not rely on it alone.\u003c\/p\u003e\n\u003cp\u003eMSM is dosed at 1,000mg. Mechanistically, MSM acts as an organosulfur donor and supports connective tissue biology while also modulating NF-kB-driven inflammation and supporting antioxidant defenses through Nrf2-related pathways. The strongest clinical range for joints is usually 1.5-3g daily, so 1g is below the most studied range, but still directionally useful in a beauty formula where sulfur donation and connective tissue support matter.\u003c\/p\u003e\n\u003cp\u003eAstrion™ is here at the full studied 490mg dose. This patented Astragalus membranaceus and Centella asiatica complex is designed to stimulate dermal fibroblasts, increasing endogenous collagen and hyaluronic acid production while also supporting improvements in skin texture, elasticity, visible pores, and brightness. This is one of the true differentiators of the formula because it targets the skin matrix directly rather than just tossing in generic antioxidants.\u003c\/p\u003e\n\u003cp\u003eSetria® L-Glutathione is included at 250mg, the entry point of the clinically supported range. Setria is the most validated oral glutathione form on the market, with human data showing that oral supplementation can raise glutathione status in blood and cells. Glutathione is the body’s central intracellular antioxidant, and in a skin-focused formula that matters because oxidative stress accelerates collagen breakdown, dullness, and environmental damage. Vitamin C at 100mg complements this by helping maintain redox cycling and supporting collagen synthesis.\u003c\/p\u003e\n\u003cp\u003eHyaluronic acid is generously dosed at 240mg as sodium hyaluronate. That is a serious oral skin hydration dose. Hyaluronic acid helps bind water within connective tissue and the skin matrix, which translates into better hydration, plumper-looking skin, and support for smoothness and elasticity over time.\u003c\/p\u003e\n\u003cp\u003eDermaval™ is included at its studied 50mg dose. This phytonutrient complex is designed to blunt elastase and collagenase activity, two enzymes that break down elastin and collagen. In simple terms, Astrion helps build more of the structure, while Dermaval helps protect what you already have.\u003c\/p\u003e\n\u003cp\u003eCeramosides™ rounds out the formula at the clinically used 30mg dose. These wheat-derived phytoceramides help restore the skin’s lipid barrier, reduce transepidermal water loss, and improve hydration and elasticity from within. They also have relevance for hair quality and shedding support, making them one of the smarter additions in a comprehensive beauty formula.\u003c\/p\u003e\n\u003cp\u003eThe synergy is the real story: MSM, vitamin C, and biotin provide baseline structural support; Astrion and hyaluronic acid help increase and hydrate the dermal matrix; Dermaval and Setria help defend that matrix from oxidative and enzymatic breakdown; Ceramosides strengthens the barrier that keeps moisture in. Core also deserves credit for full transparency: no proprietary blend, no hidden doses, and multiple trademarked actives at their real intended amounts. Expect little in the way of a “day 1” cosmetic change, but with consistent use over 2-4 weeks, most users should notice better skin hydration first, followed by improvements in softness, elasticity, nail resilience, and overall hair quality with longer use.\u003c\/p\u003e\n\u003cp class=\"sr-only\" data-citation=\"true\"\u003eCore Hair Skin Nails by Core Nutritionals contains 100mg Vitamin C, a clinical dose for health and performance.\u003c\/p\u003e\n\u003ch2\u003eKey Highlights\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e490mg Astrion™ — the full studied dose of NuLiv Science’s patented Astragalus and Centella complex. This ingredient is designed to stimulate dermal fibroblasts to increase endogenous collagen and hyaluronic acid production, which is a much more advanced strategy than relying on biotin alone.\u003c\/li\u003e\n\u003cli\u003e250mg Setria® L-Glutathione — a clinically relevant dose of the most established oral glutathione trademark in the category. Setria® has human data showing oral supplementation can raise glutathione stores, supporting antioxidant defense from the inside out.\u003c\/li\u003e\n\u003cli\u003e240mg Hyaluronic Acid — a serious oral hydration dose, not a token label sprinkle. Hyaluronic acid binds water in connective tissue and the skin matrix, supporting better moisture retention, smoother texture, and a more supple look over time.\u003c\/li\u003e\n\u003cli\u003e30mg Ceramosides™ — the clinically used dose of wheat-derived phytoceramides. These lipids help reinforce the skin barrier and reduce transepidermal water loss, which is why they are so valuable for dry, flaky, or environmentally stressed skin.\u003c\/li\u003e\n\u003cli\u003e50mg Dermaval™ — included at the researched dose used to reduce elastase and collagenase activity after a glucose challenge. In practical terms, it is designed to help protect collagen and elastin from enzymatic breakdown.\u003c\/li\u003e\n\u003cli\u003e1,000mg MSM — a meaningful connective-tissue support dose that contributes sulfur for structural proteins while also supporting inflammatory balance and antioxidant status. It is below the 1.5-3g range often studied for joints, but still smartly placed here for hair, skin, and nail support.\u003c\/li\u003e\n\u003cli\u003e5,000mcg Biotin — a robust dose of the category’s signature vitamin. While clinical evidence in healthy users is limited and Core does not pretend otherwise, this amount ensures biotin is not the limiting factor in a comprehensive beauty-support formula.\u003c\/li\u003e\n\u003cli\u003e100mg Vitamin C — a collagen-relevant support nutrient that complements glutathione and MSM. Vitamin C is required for proper collagen formation and also helps maintain antioxidant balance alongside Setria®.\u003c\/li\u003e\n\u003cli\u003eFour trademarked actives in one formula — Astrion™, Setria®, Dermaval®, and Ceramosides™. That gives this product a rare level of ingredient specificity and formulation intent compared with generic hair\/skin\/nails products built around unnamed extracts.\u003c\/li\u003e\n\u003cli\u003eFully transparent label — every active ingredient and dose is disclosed. In a category crowded with vague ‘beauty blends,’ that lets you verify exactly what you are taking against real clinical dosing ranges.\u003c\/li\u003e\n\u003cli\u003eMulti-pathway skin support — this formula does not chase one mechanism. It addresses endogenous collagen and HA production, barrier lipids, antioxidant protection, moisture retention, and structural integrity in the same daily serving.\u003c\/li\u003e\n\u003cli\u003eCapsule delivery with no sugar-heavy gummy format — better suited for fitting meaningful doses of ingredients like MSM, hyaluronic acid, and Setria®. The result is a more serious formula profile than most cosmetic supplements can physically deliver.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"sr-only\" data-citation=\"true\"\u003eCore Hair Skin Nails by Core Nutritionals contains 100mg Vitamin C, a clinical dose for health and performance.\u003c\/p\u003e\n\u003ch2\u003eWho Is This For?\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eActive women and men who already have their basics dialed in but want a more advanced beauty-support formula than a standalone biotin product. The combination of Astrion™ at 490mg, Ceramosides™ at 30mg, and hyaluronic acid at 240mg gives them targeted support for hydration, elasticity, and visible skin quality from multiple angles.\u003c\/li\u003e\n\u003cli\u003eLifters in a cutting phase whose skin, hair, and nails often take a hit when calories, dietary variety, and recovery capacity are lower. Setria® glutathione and Dermaval™ help address oxidative stress and structural protein breakdown while biotin and MSM provide foundational support.\u003c\/li\u003e\n\u003cli\u003eBusy professionals under chronic stress who notice dull skin, dryness, and weaker nails when sleep and recovery are not ideal. This formula is designed to support the skin barrier, hydration status, and antioxidant defenses rather than relying on a single trendy ingredient.\u003c\/li\u003e\n\u003cli\u003ePeople dealing with chronically dry or tight-feeling skin who want internal hydration support in addition to topical products. Hyaluronic acid at 240mg plus Ceramosides™ at 30mg is a strong oral pairing for improving moisture retention and reducing transepidermal water loss over time.\u003c\/li\u003e\n\u003cli\u003eCustomers interested in nutricosmetics who specifically want trademarked, research-backed actives rather than generic blends. Astrion™, Setria®, Dermaval®, and Ceramosides™ give this formula a level of ingredient quality rarely seen in the category.\u003c\/li\u003e\n\u003cli\u003eThose with brittle nails that split or peel easily and want more than a beauty gummy. Biotin, MSM, and vitamin C create a better foundational support stack for keratin-rich tissues, while the broader antioxidant and hydration system helps overall tissue quality.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eHow to Use\u003c\/h2\u003e\n\u003cp\u003eTake 5 capsules daily with a meal and a full glass of water. Taking it with food is practical for two reasons: it makes a 5-capsule serving easier to tolerate, and it helps turn this into a repeatable daily habit, which is exactly how ingredients like Ceramosides™, Astrion™, Setria®, and hyaluronic acid deliver their best results. You do not need to split the serving, but users sensitive to larger capsule counts can take 2 capsules with one meal and 3 with another. This is not a product you need to time around workouts because there are no stimulants and no acute performance ingredients. Do not cycle it; consistency is more important than on-off use, since the visible benefits are cumulative over weeks. It stacks well with collagen peptides, a quality protein powder, fish oil, and a general micronutrient foundation. If you use a separate high-dose biotin product, review your total intake and remember that biotin can interfere with certain lab tests. Store it in a cool, dry place and keep the bottle tightly closed to protect the capsule contents from heat and humidity.\u003c\/p\u003e\n\u003ch2\u003eWhat to Expect\u003c\/h2\u003e\n\u003cp\u003eThis is not a feel-it-in-20-minutes supplement, so the timeline is different from performance products. Days 1-7 are mostly about compliance and foundation; you are not likely to feel much immediately beyond the convenience of a once-daily capsule protocol. By weeks 2-4, skin hydration is usually the earliest noticeable change, driven primarily by hyaluronic acid and Ceramosides™ supporting water retention and barrier function. Around that same period, some users notice nails feeling harder or less prone to peeling, with MSM, biotin, and vitamin C contributing to the structural side. Weeks 4-8 are where the more cosmetic changes typically become clearer: smoother-feeling skin, better elasticity, less dryness, and improved overall tissue quality. The antioxidant and matrix-support ingredients like Setria® and Astrion™ are working in the background the whole time, but they show up as gradual improvements, not acute sensations.\u003c\/p\u003e\n\u003ch2\u003eKey Ingredients\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiotin\u003c\/strong\u003e — 5000mcg — High-potency foundational support for hair and nail structure\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMethylsulfonylmethane\u003c\/strong\u003e — 1000mg — Sulfur-rich support for connective tissue and resilience\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAstrion™\u003c\/strong\u003e — 490mg — Promotes endogenous collagen and hyaluronic acid production\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSetria® L-Glutathione\u003c\/strong\u003e — 250mg — Clinically backed antioxidant defense from inside the cell\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHyaluronic Acid\u003c\/strong\u003e — 240mg — Deep internal hydration for smoother, more supple skin\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDermaval™\u003c\/strong\u003e — 50mg — Helps protect collagen and elastin from breakdown\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCeramosides™\u003c\/strong\u003e — 30mg — Reinforces the skin barrier and moisture retention\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVitamin C\u003c\/strong\u003e — 100mg — Collagen-supportive antioxidant foundation for beauty support\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"sr-only\" data-citation=\"true\"\u003eCore Hair Skin Nails by Core Nutritionals contains 100mg Vitamin C, a clinical dose for health and performance.\u003c\/p\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003cdetails\u003e\u003csummary\u003eHow much biotin is in Core Nutritionals Hair, Skin, \u0026amp; Nails?\u003c\/summary\u003e\u003cp\u003eEach 5-capsule serving provides 5,000mcg of biotin as d-biotin. That is a high dose by category standards and well above the commonly cited 2.5mg supplemental range, although the strongest evidence for biotin remains in deficiency states rather than healthy users.\u003c\/p\u003e\u003c\/details\u003e\n\u003cdetails\u003e\u003csummary\u003eIs this just a biotin supplement with a fancy label?\u003c\/summary\u003e\u003cp\u003eNo. Biotin is only one part of the formula. The real differentiators are Astrion™ at 490mg for endogenous collagen and hyaluronic acid support, Setria® glutathione at 250mg for antioxidant defense, hyaluronic acid at 240mg for hydration, Dermaval™ at 50mg for collagen\/elastin protection, and Ceramosides™ at 30mg for skin barrier support.\u003c\/p\u003e\u003c\/details\u003e\n\u003cdetails\u003e\u003csummary\u003eHow long does it take to notice results from this formula?\u003c\/summary\u003e\u003cp\u003eMost users should think in weeks, not hours or days. Skin hydration is often the earliest noticeable change within 2-4 weeks, while improvements in overall skin texture, nail resilience, and hair quality usually become clearer with longer consistent use.\u003c\/p\u003e\u003c\/details\u003e\n\u003cdetails\u003e\u003csummary\u003eWhat makes Setria® glutathione different from generic glutathione?\u003c\/summary\u003e\u003cp\u003eSetria® is the best-known clinically studied oral glutathione trademark. Human data has shown that it can raise glutathione status in blood and cells, which is important because glutathione is the body’s primary intracellular antioxidant and a key player in detoxification and oxidative stress control.\u003c\/p\u003e\u003c\/details\u003e\n\u003cdetails\u003e\u003csummary\u003eWhy is Ceramosides™ important in a hair, skin, and nails formula?\u003c\/summary\u003e\u003cp\u003eCeramosides™ provides wheat-derived phytoceramides that help rebuild the skin’s lipid barrier. That reduces transepidermal water loss and improves hydration and elasticity, making it especially valuable for users with dry, compromised, or environmentally stressed skin.\u003c\/p\u003e\u003c\/details\u003e\n\u003cdetails\u003e\u003csummary\u003eCan I take this with collagen peptides?\u003c\/summary\u003e\u003cp\u003eYes, and that is one of the smartest ways to stack it. Astrion™ is designed to stimulate endogenous collagen and hyaluronic acid production, while collagen peptides provide additional structural amino acids and vitamin C in this formula supports collagen synthesis chemistry.\u003c\/p\u003e\u003c\/details\u003e\n\u003cdetails\u003e\u003csummary\u003eDoes this product contain stimulants or caffeine?\u003c\/summary\u003e\u003cp\u003eNo. Despite a metadata inconsistency, the verified active formula is stim-free and contains no caffeine. It can be taken any time of day based on convenience.\u003c\/p\u003e\u003c\/details\u003e\n\u003cdetails\u003e\u003csummary\u003eAre there any allergen concerns with this formula?\u003c\/summary\u003e\u003cp\u003eYes. Ceramosides™ is derived from wheat seed extract, so anyone with a wheat allergy or strong sensitivity should avoid the product unless their healthcare professional says otherwise.\u003c\/p\u003e\u003c\/details\u003e\n\u003cdetails\u003e\u003csummary\u003eShould I stop taking this before bloodwork?\u003c\/summary\u003e\u003cp\u003eYou should discuss that with your clinician, especially because the formula contains 5,000mcg of biotin. High-dose biotin can interfere with certain lab tests, including thyroid, hormone, and some cardiac markers.\u003c\/p\u003e\u003c\/details\u003e\n\u003cdetails\u003e\u003csummary\u003eHow does this compare to typical hair, skin, and nails gummies?\u003c\/summary\u003e\u003cp\u003eMost gummies are limited by space and usually lean heavily on biotin with smaller support nutrients. This capsule format allows Core to include meaningful doses of MSM, hyaluronic acid, Setria®, Astrion™, Dermaval™, and Ceramosides™ in a way gummy formats usually cannot match.\u003c\/p\u003e\u003c\/details\u003e\n\u003cdiv itemscope itemtype=\"https:\/\/schema.org\/Product\" class=\"ai-agent-data\" style=\"display:none\"\u003e\n\u003cmeta itemprop=\"name\" content=\"Core Hair Skin Nails\"\u003e\n\u003cmeta itemprop=\"brand\" content=\"Core Nutritionals\"\u003e\n\u003cmeta itemprop=\"category\" content=\"Supplement\"\u003e\n\u003cmeta itemprop=\"description\" content=\"Core Nutritionals Hair, Skin, \u0026amp; Nails is a fully disclosed, stim-free capsule formula designed to support skin hydration, barrier integrity, antioxidant defense, and the overall quality of hair and nails. Key formula stats: 8 significant active ingredients in a 5-capsule serving, with MSM 1000mg, Astrion™ 490mg, hyaluronic acid 240mg, Setria® L-glutathione 250mg, Dermaval™ 50mg, Ceramosides™ 30mg, vitamin C 100mg, and biotin 5000mcg; caffeine total is 0; form factor is capsules. Best for users s\"\u003e\n\u003cmeta itemprop=\"dateModified\" content=\"2026-04-23T12:15:03Z\"\u003e\n\u003c\/div\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":53141778628973,"sku":"core-hairskinnails1","price":54.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0581\/6021\/8173\/files\/corehairskinnailsfront.png?v=1773863091","url":"https:\/\/svpplements.com\/products\/core-nutritionals-hair-skin-nails","provider":"SVPPLEMENTS","version":"1.0","type":"link"}