Androsta-3, 5-Diene-7, 17-Dione
Aromatase Inhibition
Androsta-3, 5-Diene-7, 17-Dione, frequently referred to in the supplement industry as Arimistane, is biochemically categorized as a suicide aromatase inhibitor. The aromatase enzyme (EC 1.14.14.14) is a cytochrome P450 enzyme responsible for a critical step in the biosynthesis of estrogens; specifically, it catalyzes the aromatization of androgens (like testosterone and androstenedione) into estrogens (estradiol and estrone). As a 'suicide' or irreversible inhibitor, Androsta-3, 5-Diene-7, 17-Dione is structurally designed to bind covalently to the active site of the aromatase enzyme. Once bound, the enzyme is permanently deactivated and cannot participate in further estrogen synthesis. The body must synthesize new aromatase enzymes to restore normal estrogen conversion rates.
Cortisol Modulation
In addition to its primary role as an aromatase inhibitor, industry literature suggests that Androsta-3, 5-Diene-7, 17-Dione limits the spread and activity of cortisol. Cortisol is a primary glucocorticoid and a catabolic stress hormone that can break down muscle tissue and promote fat storage. By limiting cortisol, the compound is theorized to create a more favorable anabolic environment for muscle growth and recovery. However, the specific receptor-level interactions and signaling cascades involved in this cortisol-limiting effect are not detailed in the provided source material.
Origin and Pharmacokinetics
Androsta-3, 5-Diene-7, 17-Dione is identified as a metabolite of 7-Keto DHEA (7-oxodehydroepiandrosterone). While its parent compound is known for thermogenic properties without converting to sex hormones, Arimistane specifically targets the estrogen pathway. Due to a lack of clinical data in the provided sources (with primary databases returning a 404 error), detailed pharmacokinetic parameters—including Tmax, oral bioavailability, half-life, and specific metabolic clearance rates—remain characterized by insufficient data.
What is Androsta-3, 5-Diene-7, 17-Dione? +
What is Arimistane? +
How does it work? +
What is a suicide aromatase inhibitor? +
What is the recommended dose? +
Does it lower cortisol? +
Is it a prohormone? +
What is E-Xstane? +
Are there clinical studies on it? +
Can women take it? +
Will it build muscle? +
Does it cause side effects? +
Is it banned in sports? +
How long does it take to work? +
Can it be stacked? +
What are the food sources? +
Is a loading phase required? +
Everything About Androsta-3, 5-Diene-7, 17-Dione Article
What It Does Androsta-3, 5-Diene-7, 17-Dione, widely known in the sports nutrition industry as Arimistane, is a dietary supplement ingredient categorized as a hormone supporter and aromatase inhibitor (AI). Biochemically, it is a metabolite of 7-Keto DHEA. Its primary function is to manage and restrict the body's production of estrogen. By keeping estrogen levels "under wraps," it is marketed to men seeking to increase lean muscle gains, improve vascularity, and enhance overall vitality.
The Science The core mechanism of Androsta-3, 5-Diene-7, 17-Dione lies in its action as a "suicide" aromatase inhibitor. The aromatase enzyme is responsible for the conversion of androgens (like testosterone) into estrogens. When a compound acts as a suicide inhibitor, it binds irreversibly to the aromatase enzyme. This permanent binding deactivates the enzyme entirely, meaning the body cannot use it to produce estrogen and must synthesize new enzymes to resume normal estrogen production.
Furthermore, industry literature suggests that this compound limits the spread of cortisol. Cortisol is a stress hormone that, when chronically elevated, can lead to muscle breakdown (catabolism) and fat accumulation. By inhibiting both estrogen and cortisol, Androsta-3, 5-Diene-7, 17-Dione aims to create a highly anabolic environment conducive to strength and muscle growth.
What The Research Says Currently, there is insufficient clinical data available in the provided sources to establish a robust scientific consensus on Androsta-3, 5-Diene-7, 17-Dione. Primary scientific databases and independent review sites (such as Examine.com) currently lack dedicated evidence pages or peer-reviewed summaries for this specific compound. The claims regarding its efficacy as an aromatase inhibitor and cortisol modulator are derived primarily from supplement industry literature and manufacturer marketing materials. No specific randomized controlled trials (RCTs) or meta-analyses have been provided to verify its safety, efficacy, or long-term effects in human subjects.
Dosing Guide Based on a survey of 14 products currently on the market, the typical dosage for Androsta-3, 5-Diene-7, 17-Dione ranges from 37.5mg to 75mg per serving. Median Dose: 50mg Mean Dose: 55.7mg Minimum Observed Dose: 36mg (as seen in specific branded formulations like InnovaPharm's Stage 1 Evolution Rejuvenation).
Due to the lack of clinical trials, a scientifically validated "optimal" dose cannot be confirmed; users generally rely on manufacturer recommendations.
Forms Compared Androsta-3, 5-Diene-7, 17-Dione is available in generic forms (often listed simply by its chemical nomenclature or as Arimistane) and in trademarked extracts. One such trademarked version is E-Xstane, utilized by brands like InnovaPharm. While trademarked versions often claim higher purity or specific extraction standards, there is insufficient clinical data provided to compare the bioavailability or efficacy of E-Xstane against generic arimistane directly.
When & How To Take It Because it is utilized for long-term hormonal modulation rather than acute pre-workout effects, timing is generally less critical than consistency. Users typically follow the specific instructions provided on the product label. There is insufficient data to recommend a specific loading protocol or optimal time of day for ingestion.
Stacking Androsta-3, 5-Diene-7, 17-Dione is frequently stacked or formulated alongside natural testosterone boosters. For example, it is often combined with herbal extracts designed to promote the activation of various hormonal pathways. The goal of these stacks is to simultaneously boost endogenous testosterone while using the arimistane to prevent that new testosterone from aromatizing into estrogen.
Who Should Take It This ingredient is primarily marketed toward adult men, specifically bodybuilders and strength athletes, who are looking to optimize their testosterone-to-estrogen ratio. It appeals to those seeking a leaner, drier, and more vascular physique by minimizing estrogen-related water retention.
Who Should NOT Take It Due to its mechanism of action, Androsta-3, 5-Diene-7, 17-Dione should be avoided by several populations: Tested Athletes: As an aromatase inhibitor that alters hormone levels, it is highly likely to trigger a positive result on anti-doping tests and is banned by organizations like WADA. Women and Minors: Hormonal modulators of this nature are generally contraindicated for women and individuals under 18 due to the risk of severe endocrine disruption. Individuals with Medical Conditions: Anyone with a history of endocrine disorders should consult a physician before use.
The Bottom Line Androsta-3, 5-Diene-7, 17-Dione (Arimistane) is an aggressive, over-the-counter suicide aromatase inhibitor used by bodybuilders to manage estrogen and cortisol. While market data shows standard dosing between 37.5mg and 75mg, the compound currently lacks robust clinical validation in the provided literature. Users should approach with caution, keeping in mind its status as a potent hormonal modulator and its potential implications for drug-tested sports.