Indole-3-Carbinol
I3C is rapidly oligomerized in gastric acid (pH <3) to DIM and higher-order indole oligomers. DIM reaches peak plasma concentrations following oral doses of 200mg (reported Cmax ~104 ng/mL in some pharmacokinetic analyses, though this figure requires independent verification). I3C itself is largely undetectable in plasma post-ingestion. CYP1A1/1A2 induction is the most clinically relevant pharmacokinetic interaction, with implications for drug metabolism. Half-life data for DIM are not well-established in published literature. Bioavailability of I3C per se is low due to pre-systemic conversion.
What is Indole-3-Carbinol (I3C)? +
How does Indole-3-Carbinol work? +
What is the recommended dosage for Indole-3-Carbinol? +
When is the best time to take Indole-3-Carbinol? +
Are there any side effects of taking Indole-3-Carbinol? +
Do I need to cycle Indole-3-Carbinol? +
What is the best form of Indole-3-Carbinol to take? +
Who should take Indole-3-Carbinol? +
Who should not take Indole-3-Carbinol? +
Can I stack Indole-3-Carbinol with other supplements? +
Is Indole-3-Carbinol safe for long-term use? +
Can I get Indole-3-Carbinol from food? +
Is there a difference between branded and generic Indole-3-Carbinol? +
Do I need a loading phase for Indole-3-Carbinol? +
Does Indole-3-Carbinol interact with medications? +
Everything About Indole-3-Carbinol Article
What is Indole-3-Carbinol?
Indole-3-Carbinol (I3C) is a compound found in cruciferous vegetables like broccoli, cabbage, and cauliflower. It is categorized as an antioxidant and is available as a dietary supplement. The provided sources note its presence in over 10 products, indicating some market presence.
The Science: How Does It Work?
Unfortunately, the provided source materials did not contain scientific information detailing the mechanism of action for Indole-3-Carbinol. Key data regarding its effects on biochemical pathways, enzymes, and cellular receptors were unavailable for synthesis.
What The Research Says
There was no clinical research, such as randomized controlled trials or meta-analyses, included in the source documents. The primary evidence source, an Examine.com page, was inaccessible (404 error). Therefore, no claims about the efficacy or benefits of Indole-3-Carbinol can be substantiated based on the provided information.
Dosing Guide
A survey of 9 commercially available products containing Indole-3-Carbinol found that dosages typically range from 100mg to 200mg per serving. The median dose was 160mg. As no clinical studies were provided, this range reflects market trends rather than clinically validated effective doses.
Forms Compared
The provided sources did not mention or compare different forms of Indole-3-Carbinol.
When & How To Take It
Information regarding optimal timing, cycling, or whether to take I3C with food was not present in the source materials.
Stacking
One product mentioned in the sources combines Indole-3-Carbinol with resveratrol and broccoli seed extract. However, the rationale for this combination and whether it has been studied for synergistic effects was not specified.
Who Should Take It
The provided information is insufficient to make a recommendation for any specific population.
Who Should NOT Take It
The provided information did not contain any data on contraindications, safety, or populations who should avoid taking Indole-3-Carbinol.
The Bottom Line
Based strictly on the provided sources, Indole-3-Carbinol is a supplement ingredient with typical market doses between 100mg and 200mg. However, due to a lack of accessible scientific literature and clinical studies in the source material, no conclusions can be drawn about its mechanism, effectiveness, benefits, or safety.