// start_here
what dose do I need?which pre-workout has the most?safe with my meds?
Nb
Indole-3-Ca.

Indole-3-Carbinol

estrogen-metabolism-modulator, antioxidant, chemopreventive-agent· General
C-Tier · Limited Evidence43 citations
Found in 10 products
Mechanism of Action +

I3C is rapidly oligomerized in gastric acid (pH <3) to DIM and higher-order indole oligomers. DIM reaches peak plasma concentrations following oral doses of 200mg (reported Cmax ~104 ng/mL in some pharmacokinetic analyses, though this figure requires independent verification). I3C itself is largely undetectable in plasma post-ingestion. CYP1A1/1A2 induction is the most clinically relevant pharmacokinetic interaction, with implications for drug metabolism. Half-life data for DIM are not well-established in published literature. Bioavailability of I3C per se is low due to pre-systemic conversion.

I3C is rapidly oligomerized in gastric acid (pH <3) to DIM and higher-order indole oligomers. DIM reaches peak plasma concentrations following oral doses of 200mg (reported Cmax ~104 ng/mL in some pharmacokinetic analyses, though this figure requires independent verification). I3C itself is largely undetectable in plasma post-ingestion. CYP1A1/1A2 induction is the most clinically relevant pharmacokinetic interaction, with implications for drug metabolism. Half-life data for DIM are not well-established in published literature. Bioavailability of I3C per se is low due to pre-systemic conversion.
Works Best With
DIM (3,3'-Diindolylmethane)
Broccoli Seed Extract (Sulforaphane)
Resveratrol
DIM (3,3'-Diindolylmethane)
DIM is the primary active metabolite of I3C. Some formulations combine both compounds, though I3C converts to DIM endogenously. The combination has not been formally studied as superior to either alone.
Broccoli Seed Extract (Sulforaphane)
Sulforaphane from broccoli seed extract also activates Nrf2 and CYP enzymes via complementary pathways. Co-occurrence in commercial products is common; synergistic human RCT data are lacking.
Resveratrol
Co-formulated in some commercial products. Both compounds have proposed chemopreventive properties but their combination has not been studied in human trials for additive or synergistic effects.
Questions About Indole-3-Carbinol
What is Indole-3-Carbinol (I3C)? +
Indole-3-Carbinol, also known as I3C, is a compound naturally found in cruciferous vegetables like broccoli, cauliflower, and cabbage. It is sold as a dietary supplement and is categorized as an antioxidant. The provided sources did not contain further details on its specific functions.
How does Indole-3-Carbinol work? +
The provided sources do not contain information on the mechanism of action for Indole-3-Carbinol. Details about its effects on biochemical pathways or enzymes were not available.
What is the recommended dosage for Indole-3-Carbinol? +
The provided sources did not include clinically recommended dosages. However, a survey of commercial products shows a common dosage range of 100mg to 200mg per serving.
When is the best time to take Indole-3-Carbinol? +
Insufficient data from provided sources. There was no information regarding the optimal timing for taking I3C, or whether it should be taken with or without food.
Are there any side effects of taking Indole-3-Carbinol? +
The provided source materials did not contain any information about the safety or potential side effects of Indole-3-Carbinol supplementation.
Do I need to cycle Indole-3-Carbinol? +
There is no information in the provided sources to suggest whether cycling Indole-3-Carbinol is necessary or beneficial.
What is the best form of Indole-3-Carbinol to take? +
The provided sources did not discuss or compare different forms of Indole-3-Carbinol, so a recommendation cannot be made.
Who should take Indole-3-Carbinol? +
Based on the limited information in the provided sources, it is not possible to determine who might benefit from taking Indole-3-Carbinol.
Who should not take Indole-3-Carbinol? +
The provided sources did not contain any information on contraindications or populations that should avoid I3C supplementation.
Can I stack Indole-3-Carbinol with other supplements? +
One commercial product mentioned in the sources combines I3C with resveratrol and broccoli seed extract. However, no scientific rationale or evidence for this stack was provided.
Is Indole-3-Carbinol safe for long-term use? +
The provided sources did not contain any data regarding the long-term safety of Indole-3-Carbinol supplementation.
Can I get Indole-3-Carbinol from food? +
Yes, Indole-3-Carbinol is naturally present in cruciferous vegetables. Examples include broccoli, cabbage, kale, and cauliflower.
Is there a difference between branded and generic Indole-3-Carbinol? +
The provided sources did not mention any specific trademarked or branded forms of Indole-3-Carbinol, so a comparison cannot be made.
Do I need a loading phase for Indole-3-Carbinol? +
There was no mention of a loading phase for Indole-3-Carbinol in the provided source materials.
Does Indole-3-Carbinol interact with medications? +
Insufficient data from provided sources. No information regarding potential interactions between Indole-3-Carbinol and medications was available.
Deep Content
Everything About Indole-3-Carbinol Article

## What is Indole-3-Carbinol?

Indole-3-Carbinol (I3C) is a compound found in cruciferous vegetables like broccoli, cabbage, and cauliflower. It is categorized as an antioxidant and is available as a dietary supplement. The provided sources note its presence in over 10 products, indicating some market presence.

## The Science: How Does It Work?

Unfortunately, the provided source materials did not contain scientific information detailing the mechanism of action for Indole-3-Carbinol. Key data regarding its effects on biochemical pathways, enzymes, and cellular receptors were unavailable for synthesis.

## What The Research Says

There was no clinical research, such as randomized controlled trials or meta-analyses, included in the source documents. The primary evidence source, an Examine.com page, was inaccessible (404 error). Therefore, no claims about the efficacy or benefits of Indole-3-Carbinol can be substantiated based on the provided information.

## Dosing Guide

A survey of 9 commercially available products containing Indole-3-Carbinol found that dosages typically range from **100mg to 200mg** per serving. The median dose was 160mg. As no clinical studies were provided, this range reflects market trends rather than clinically validated effective doses.

## Forms Compared

The provided sources did not mention or compare different forms of Indole-3-Carbinol.

## When & How To Take It

Information regarding optimal timing, cycling, or whether to take I3C with food was not present in the source materials.

## Stacking

One product mentioned in the sources combines Indole-3-Carbinol with resveratrol and broccoli seed extract. However, the rationale for this combination and whether it has been studied for synergistic effects was not specified.

## Who Should Take It

The provided information is insufficient to make a recommendation for any specific population.

## Who Should NOT Take It

The provided information did not contain any data on contraindications, safety, or populations who should avoid taking Indole-3-Carbinol.

## The Bottom Line

Based strictly on the provided sources, Indole-3-Carbinol is a supplement ingredient with typical market doses between 100mg and 200mg. However, due to a lack of accessible scientific literature and clinical studies in the source material, no conclusions can be drawn about its mechanism, effectiveness, benefits, or safety.

📱 Questions about Indole-3-Carbinol?
Text us your goals. We'll match you to the right product and dose.
Real humans + SuppVault AI · Msg rates apply · Reply STOP
← Back to Supplement Periodic Table
Shop All 10 Products with Indole-3-Carbinol →