Proprietary blend with Explotab(TM) Technology
Mechanism of Action +
### Polymer Chemistry of Sodium Starch Glycolate Sodium starch glycolate (SSG), the generic equivalent of Explotab™, is a sodium salt of a carboxymethyl ether of starch. It is synthesized by cross-linking and carboxymethylating potato starch. The carboxymethylation process introduces hydrophilic carboxymethyl groups into the starch polymer chain, which drastically increases its affinity for water (hydrophilicity). However, if native starch is merely made more hydrophilic, it tends to dissolve into a viscous, sticky gel upon contact with water. This gel formation is counterproductive in tablet formulation because it creates a barrier that prevents further water penetration, thereby trapping the active pharmaceutical ingredients (APIs) inside a gummy matrix—a phenomenon known as 'gel blocking.'
To prevent gel blocking, the starch is chemically cross-linked. Cross-linking creates a three-dimensional network that prevents the polymer chains from fully separating and dissolving in water. Instead of dissolving, the cross-linked polymer network absorbs water and expands. The degree of cross-linking and the degree of substitution (the number of carboxymethyl groups per glucose unit) are meticulously controlled during the manufacturing of Explotab™ to optimize its swelling capacity. The result is an excipient that can absorb massive amounts of water rapidly without forming a restrictive gel layer.
### The Thermodynamics of Hydration and Swelling The primary mechanism of action for Explotab™ is swelling. When a tablet containing Explotab™ is ingested and reaches the aqueous environment of the stomach, water molecules penetrate the tablet matrix via capillary action (wicking). As water reaches the Explotab™ particles, the hydrophilic carboxymethyl groups rapidly hydrate. The thermodynamic drive for water to enter the polymer network causes the particles to swell to 7 to 12 times their original volume in a matter of seconds.
This rapid, multidirectional volumetric expansion generates immense internal stress within the tablet matrix. Because the tablet was compressed under high pressure during manufacturing, the sudden internal expansion overcomes the cohesive forces holding the tablet together. The tablet literally explodes from the inside out (hence the trademark name 'Explotab'), disintegrating into primary constituent particles.
### Impact on Pharmacokinetics: Tmax and Cmax Optimization The disintegration of a tablet is the critical first step in the absorption of any solid oral dosage form. According to the Noyes-Whitney equation, the rate of dissolution is directly proportional to the surface area of the dissolving solid. By rapidly breaking the tablet down into fine particles, Explotab™ exponentially increases the surface area of the active ingredients exposed to the gastrointestinal fluids.
For poorly water-soluble compounds (which make up a large percentage of modern dietary supplements and botanicals), dissolution is the rate-limiting step for systemic absorption. By utilizing Explotab™, formulators can significantly accelerate the dissolution rate. Pharmacokinetically, this translates to a shorter Tmax (the time it takes to reach maximum plasma concentration) and often a higher Cmax (the maximum plasma concentration achieved). In the context of sports nutrition—such as pre-workouts or acute pain relievers like Hi-Tech Pharmaceuticals' Pain-Rx—achieving a rapid Tmax is crucial for the user to 'feel' the effects quickly.
### Interaction with Hydrophobic Active Ingredients Many active ingredients in sports supplements, such as certain botanical extracts (e.g., Tribulus, Guggulsterones found in Glucozene-Rx), are highly hydrophobic. When compressed into a tablet, these hydrophobic ingredients naturally repel water, leading to prolonged disintegration times and poor bioavailability. Explotab™ is particularly effective in these formulations. Because its swelling force is so powerful, it can overcome the hydrophobic nature of the surrounding active ingredients, forcing water into the matrix and ensuring that even the most stubborn, tightly compressed tablets break down efficiently in the digestive tract. Studies comparing SSG to other disintegrants like microcrystalline cellulose (MCC) show that SSG relies heavily on this swelling mechanism, making it superior for formulations where wicking alone is insufficient.
What does proprietary nootropic blend mean? +
What's in proprietary blend? +
Is sodium starch glycolate safe to use? +
What is croscarmellose sodium used for in pharmaceuticals? +
What is sodium starch glycolate derived from? +
What is sodium starch glycolate used for in pharmaceuticals? +
What is Explotab? +
How does Explotab work in the body? +
Is Explotab an active ingredient? +
Why do supplement companies use superdisintegrants? +
Does Explotab cause bloating or gas? +
Can I take supplements with Explotab on an empty stomach? +
What is the difference between Explotab and Primojel? +
How fast do tablets with Explotab break down? +
Is sodium starch glycolate gluten-free? +
Does Explotab interact with other medications? +
Why is Explotab listed in a proprietary blend? +
What is Extend-Rx Technology? +
Everything About Proprietary blend with Explotab(TM) Technology Article
## Introduction to Advanced Delivery Systems When consumers purchase a dietary supplement, they often focus entirely on the active ingredients—the vitamins, the amino acids, or the exotic botanical extracts. However, clinical biochemists and formulation scientists know a fundamental truth: an active ingredient is completely useless if it cannot be absorbed by the body.
One of the most common issues in the supplement industry is the production of 'rock hard' tablets. To fit large doses of ingredients into a single pill, manufacturers use immense pressure during the tableting process. Without the proper delivery technology, these tightly compressed tablets can pass entirely through the human digestive tract without fully breaking down. This results in wasted money and zero physiological benefit. Enter superdisintegrants, and specifically, Explotab™ Technology.
## What is Explotab™? Explotab™ is a trademarked brand name for **sodium starch glycolate**, a highly specialized pharmaceutical excipient. It belongs to a class of inactive ingredients known as 'superdisintegrants.'
Manufactured by JRS Pharma, Explotab™ is created by taking natural potato starch and subjecting it to two chemical processes: carboxymethylation and cross-linking. 1. **Carboxymethylation** makes the starch incredibly hydrophilic, meaning it aggressively attracts water. 2. **Cross-linking** binds the starch molecules together in a 3D web. This prevents the starch from simply dissolving into a sticky gel when it hits water.
The result is a powder that, when exposed to the fluids in your stomach, acts like a microscopic sponge on steroids. It rapidly absorbs water and swells to 7 to 12 times its original size in a matter of seconds.
## The Physics of Superdisintegrants: How It Works Imagine a tightly packed brick of dry sand. If you pour water on it, the water might just pool on top or slowly seep in. Now imagine that mixed into that sand are thousands of tiny balloons that instantly inflate the moment they touch water. The inflating balloons would violently push the sand apart, shattering the brick into millions of individual grains.
This is exactly how Explotab™ works inside a supplement tablet. When you swallow a tablet containing Explotab™, the water in your stomach wicks into the pill. The Explotab™ particles instantly hydrate and undergo massive volumetric expansion. This internal swelling generates so much outward force that it overcomes the mechanical strength of the tablet, causing it to literally explode from the inside out.
By shattering the tablet into fine particles, Explotab™ exponentially increases the surface area of the active ingredients. According to the laws of physical chemistry (specifically the Noyes-Whitney equation), greater surface area equals faster dissolution. And in the human body, faster dissolution equals faster and more complete absorption into the bloodstream.
## Explotab vs. Other Disintegrants Not all disintegrants are created equal. Older, cheaper supplements might use standard corn starch or microcrystalline cellulose (MCC) to help tablets break apart. However, clinical studies have shown that these traditional excipients are vastly inferior to modern superdisintegrants.
In a 2012 study published in the assessment of disintegrants, researchers compared sodium starch glycolate (Explotab) against croscarmellose sodium, crospovidone, and MCC. The study found that MCC relies on a 'wicking' mechanism—it pulls water in, but doesn't swell much. Crospovidone also relies on wicking and shape recovery. Sodium starch glycolate, however, was identified as the material with the largest swelling capacity. For tablets packed with hydrophobic (water-repelling) ingredients—like many herbal sports supplements—the sheer mechanical force of Explotab's swelling is often the only way to guarantee the tablet breaks apart.
## Why Supplement Companies Use Proprietary Delivery Blends You will often see Explotab™ listed on the labels of advanced sports nutrition brands, such as Hi-Tech Pharmaceuticals, sometimes bundled into a 'Proprietary Blend with Explotab and Extend-Rx Technology.'
Why list an inactive excipient in a proprietary blend? 1. **Marketing:** It highlights that the company is using expensive, pharmaceutical-grade delivery systems rather than cheap manufacturing techniques. 2. **Biphasic Release:** By combining Explotab (which causes immediate, explosive rapid release) with Extend-Rx (which causes slow, sustained release), formulators can create a product that hits you quickly but lasts for hours. This is highly desirable in products like pre-workouts, fat burners, or pain management supplements (like Pain-Rx).
## Safety, Tolerability, and Excipient Status Sodium starch glycolate is universally recognized as safe. It is an FDA-approved excipient used in thousands of over-the-counter and prescription medications worldwide. Because it is an inactive polymer, it is not absorbed into the bloodstream; it simply does its mechanical job in the stomach and passes harmlessly through the digestive tract.
While it is derived from potato starch, the rigorous chemical processing and purification mean it is generally safe even for those with mild food sensitivities, and it is entirely gluten-free.
## Conclusion While it may not be the ingredient that builds muscle or burns fat, Explotab™ Technology is the unsung hero of high-quality supplement formulations. By ensuring that tightly compressed tablets disintegrate rapidly and completely, Explotab™ guarantees that you are actually absorbing the active ingredients you paid for, leading to faster onset times and better overall clinical outcomes.