// start_here
what dose do I need?which pre-workout has the most?safe with my meds?
PR
Proprietary.

Proprietary blend with Explotab(TM) Technology

other· General
A-Tier · Strong Evidence
Found in 1 products
Mechanism of Action +

### Polymer Chemistry of Sodium Starch Glycolate Sodium starch glycolate (SSG), the generic equivalent of Explotab™, is a sodium salt of a carboxymethyl ether of starch. It is synthesized by cross-linking and carboxymethylating potato starch. The carboxymethylation process introduces hydrophilic carboxymethyl groups into the starch polymer chain, which drastically increases its affinity for water (hydrophilicity). However, if native starch is merely made more hydrophilic, it tends to dissolve into a viscous, sticky gel upon contact with water. This gel formation is counterproductive in tablet formulation because it creates a barrier that prevents further water penetration, thereby trapping the active pharmaceutical ingredients (APIs) inside a gummy matrix—a phenomenon known as 'gel blocking.'

To prevent gel blocking, the starch is chemically cross-linked. Cross-linking creates a three-dimensional network that prevents the polymer chains from fully separating and dissolving in water. Instead of dissolving, the cross-linked polymer network absorbs water and expands. The degree of cross-linking and the degree of substitution (the number of carboxymethyl groups per glucose unit) are meticulously controlled during the manufacturing of Explotab™ to optimize its swelling capacity. The result is an excipient that can absorb massive amounts of water rapidly without forming a restrictive gel layer.

### The Thermodynamics of Hydration and Swelling The primary mechanism of action for Explotab™ is swelling. When a tablet containing Explotab™ is ingested and reaches the aqueous environment of the stomach, water molecules penetrate the tablet matrix via capillary action (wicking). As water reaches the Explotab™ particles, the hydrophilic carboxymethyl groups rapidly hydrate. The thermodynamic drive for water to enter the polymer network causes the particles to swell to 7 to 12 times their original volume in a matter of seconds.

This rapid, multidirectional volumetric expansion generates immense internal stress within the tablet matrix. Because the tablet was compressed under high pressure during manufacturing, the sudden internal expansion overcomes the cohesive forces holding the tablet together. The tablet literally explodes from the inside out (hence the trademark name 'Explotab'), disintegrating into primary constituent particles.

### Impact on Pharmacokinetics: Tmax and Cmax Optimization The disintegration of a tablet is the critical first step in the absorption of any solid oral dosage form. According to the Noyes-Whitney equation, the rate of dissolution is directly proportional to the surface area of the dissolving solid. By rapidly breaking the tablet down into fine particles, Explotab™ exponentially increases the surface area of the active ingredients exposed to the gastrointestinal fluids.

For poorly water-soluble compounds (which make up a large percentage of modern dietary supplements and botanicals), dissolution is the rate-limiting step for systemic absorption. By utilizing Explotab™, formulators can significantly accelerate the dissolution rate. Pharmacokinetically, this translates to a shorter Tmax (the time it takes to reach maximum plasma concentration) and often a higher Cmax (the maximum plasma concentration achieved). In the context of sports nutrition—such as pre-workouts or acute pain relievers like Hi-Tech Pharmaceuticals' Pain-Rx—achieving a rapid Tmax is crucial for the user to 'feel' the effects quickly.

### Interaction with Hydrophobic Active Ingredients Many active ingredients in sports supplements, such as certain botanical extracts (e.g., Tribulus, Guggulsterones found in Glucozene-Rx), are highly hydrophobic. When compressed into a tablet, these hydrophobic ingredients naturally repel water, leading to prolonged disintegration times and poor bioavailability. Explotab™ is particularly effective in these formulations. Because its swelling force is so powerful, it can overcome the hydrophobic nature of the surrounding active ingredients, forcing water into the matrix and ensuring that even the most stubborn, tightly compressed tablets break down efficiently in the digestive tract. Studies comparing SSG to other disintegrants like microcrystalline cellulose (MCC) show that SSG relies heavily on this swelling mechanism, making it superior for formulations where wicking alone is insufficient.

Works Best With
Poorly soluble botanical extracts (e.g., Guggulsterones, Tribulus)
Explotab forces the rapid breakdown of tightly compressed botanical tablets, ensuring the hydrophobic plant compounds are exposed to digestive enzymes and bile salts quickly.
Extend-Rx Technology
Often paired in proprietary blends (like in Hi-Tech Pharmaceuticals products) to create a biphasic release profile: Explotab provides an immediate rapid release of a portion of the dose, while Extend-Rx provides a sustained release of the remainder.
Questions About Proprietary blend with Explotab(TM) Technology
What does proprietary nootropic blend mean? +
A proprietary nootropic blend is a custom mixture of cognitive-enhancing ingredients where the manufacturer lists the total weight of the blend, but not the exact dose of each individual ingredient. Companies use this to protect their specific formulation ratios from competitors. Sometimes, advanced delivery technologies like Explotab are included in these blends to ensure the nootropics are absorbed quickly.
What's in proprietary blend? +
A proprietary blend contains a mixture of active ingredients (like herbs, amino acids, or vitamins) and sometimes specialized delivery excipients (like Explotab). The FDA requires all ingredients in the blend to be listed in descending order of predominance by weight, but the exact milligram amount of each specific ingredient is kept secret.
Is sodium starch glycolate safe to use? +
Yes, sodium starch glycolate is highly safe and universally approved for use in pharmaceuticals and dietary supplements. It is an inactive, non-toxic excipient that simply swells in water to break apart tablets and is then passed harmlessly through the digestive tract.
What is croscarmellose sodium used for in pharmaceuticals? +
Croscarmellose sodium is another type of superdisintegrant used in pharmaceuticals to help tablets break apart in the stomach. Like sodium starch glycolate, it improves the bioavailability of drugs, but it is derived from cross-linked cellulose rather than starch.
What is sodium starch glycolate derived from? +
Sodium starch glycolate is primarily derived from natural potato starch. The starch undergoes chemical processes—specifically cross-linking and carboxymethylation—to enhance its ability to absorb water and swell rapidly without forming a sticky gel.
What is sodium starch glycolate used for in pharmaceuticals? +
In pharmaceuticals, sodium starch glycolate is used as a superdisintegrant. It is added to tablet and capsule formulations to ensure that the pill rapidly breaks apart upon reaching the stomach, which is essential for the active drugs to dissolve and be absorbed into the bloodstream.
What is Explotab? +
Explotab is a trademarked brand name for sodium starch glycolate, manufactured by JRS Pharma. It is a premium, pharmaceutical-grade superdisintegrant used to improve the absorption of dietary supplements and medications.
How does Explotab work in the body? +
When a tablet containing Explotab reaches the stomach, the Explotab particles rapidly absorb gastric fluids and swell to 7-12 times their original size. This massive internal expansion shatters the tablet into tiny particles, allowing the active ingredients to be absorbed much faster.
Is Explotab an active ingredient? +
No, Explotab is an inactive excipient. It does not have any direct physiological effect on the body (like building muscle or burning fat); its sole purpose is to improve the delivery and absorption of the actual active ingredients in the supplement.
Why do supplement companies use superdisintegrants? +
Supplement companies use superdisintegrants to prevent their tablets from passing through the digestive tract undissolved. Because many supplements require large doses compressed tightly into a single pill, a superdisintegrant is necessary to ensure the pill actually breaks down so the user gets the benefits.
Does Explotab cause bloating or gas? +
No, Explotab does not cause bloating or gas. It is used in very small quantities (typically 2-8% of a single tablet's weight), which is a microscopically small amount of modified starch that will not trigger gastrointestinal distress.
Can I take supplements with Explotab on an empty stomach? +
Yes, the presence of Explotab does not dictate whether a supplement should be taken with food. You should follow the specific directions for the active ingredients in the product. Explotab will work effectively to break down the tablet with or without food, provided there is some fluid in the stomach.
What is the difference between Explotab and Primojel? +
Explotab and Primojel are both trademarked brand names for the exact same chemical compound: sodium starch glycolate. They are manufactured by different companies but serve the identical function of acting as a superdisintegrant in solid dosage forms.
How fast do tablets with Explotab break down? +
Tablets formulated with an optimal amount of Explotab typically begin to disintegrate within seconds of contacting stomach fluids, and completely break down into primary particles within 5 to 15 minutes.
Is sodium starch glycolate gluten-free? +
Yes, sodium starch glycolate is gluten-free. It is derived from potato starch, not wheat, barley, or rye, making it completely safe for individuals with Celiac disease or non-celiac gluten sensitivity.
Does Explotab interact with other medications? +
Explotab itself does not chemically interact with other medications. However, because it speeds up the absorption of the active ingredients it is paired with, it can alter the pharmacokinetics (how fast a drug hits your system) of that specific formulation.
Why is Explotab listed in a proprietary blend? +
Some brands, like Hi-Tech Pharmaceuticals, list Explotab in their proprietary blends to highlight their advanced delivery systems. It signals to the consumer that the product uses pharmaceutical-grade technology to ensure rapid absorption, differentiating it from cheaper competitors.
What is Extend-Rx Technology? +
Extend-Rx is another proprietary delivery technology often paired with Explotab. While Explotab causes rapid, immediate release of ingredients, Extend-Rx is designed to slow down absorption. By combining both, manufacturers can create a supplement that hits you quickly but continues to work for several hours.
Research Highlights
Rojas J, Guisao S, Ruge V., 2012in vitro
Functional assessment of four types of disintegrants and the
Sodium starch glycolate and croscarmellose sodium act primarily via a swelling mechanism. SSG was identified as the largest swelling material, significantly aiding in the disintegration of poorly soluble drugs like spironolactone.
Khan HU, Hanif M, Sarfraz RM, et al., 2017in vitro
Development and evaluation of novel antihypertensive orodisp
Formulations containing 2% Sodium starch glycolate and 6% pregelatinized starch were found to be the best regarding disintegration time, wetting volume, and drug release for orodispersible tablets.
Desai PM, Er PX, Liew CV, Heng PW., 2014in vitro
Functionality of disintegrants and their mixtures in enablin
Investigation of disintegrants confirmed that optimizing the type and concentration of superdisintegrants like SSG is critical for enabling fast disintegration of solid dosage forms.
Deep Content
Everything About Proprietary blend with Explotab(TM) Technology Article

## Introduction to Advanced Delivery Systems When consumers purchase a dietary supplement, they often focus entirely on the active ingredients—the vitamins, the amino acids, or the exotic botanical extracts. However, clinical biochemists and formulation scientists know a fundamental truth: an active ingredient is completely useless if it cannot be absorbed by the body.

One of the most common issues in the supplement industry is the production of 'rock hard' tablets. To fit large doses of ingredients into a single pill, manufacturers use immense pressure during the tableting process. Without the proper delivery technology, these tightly compressed tablets can pass entirely through the human digestive tract without fully breaking down. This results in wasted money and zero physiological benefit. Enter superdisintegrants, and specifically, Explotab™ Technology.

## What is Explotab™? Explotab™ is a trademarked brand name for **sodium starch glycolate**, a highly specialized pharmaceutical excipient. It belongs to a class of inactive ingredients known as 'superdisintegrants.'

Manufactured by JRS Pharma, Explotab™ is created by taking natural potato starch and subjecting it to two chemical processes: carboxymethylation and cross-linking. 1. **Carboxymethylation** makes the starch incredibly hydrophilic, meaning it aggressively attracts water. 2. **Cross-linking** binds the starch molecules together in a 3D web. This prevents the starch from simply dissolving into a sticky gel when it hits water.

The result is a powder that, when exposed to the fluids in your stomach, acts like a microscopic sponge on steroids. It rapidly absorbs water and swells to 7 to 12 times its original size in a matter of seconds.

## The Physics of Superdisintegrants: How It Works Imagine a tightly packed brick of dry sand. If you pour water on it, the water might just pool on top or slowly seep in. Now imagine that mixed into that sand are thousands of tiny balloons that instantly inflate the moment they touch water. The inflating balloons would violently push the sand apart, shattering the brick into millions of individual grains.

This is exactly how Explotab™ works inside a supplement tablet. When you swallow a tablet containing Explotab™, the water in your stomach wicks into the pill. The Explotab™ particles instantly hydrate and undergo massive volumetric expansion. This internal swelling generates so much outward force that it overcomes the mechanical strength of the tablet, causing it to literally explode from the inside out.

By shattering the tablet into fine particles, Explotab™ exponentially increases the surface area of the active ingredients. According to the laws of physical chemistry (specifically the Noyes-Whitney equation), greater surface area equals faster dissolution. And in the human body, faster dissolution equals faster and more complete absorption into the bloodstream.

## Explotab vs. Other Disintegrants Not all disintegrants are created equal. Older, cheaper supplements might use standard corn starch or microcrystalline cellulose (MCC) to help tablets break apart. However, clinical studies have shown that these traditional excipients are vastly inferior to modern superdisintegrants.

In a 2012 study published in the assessment of disintegrants, researchers compared sodium starch glycolate (Explotab) against croscarmellose sodium, crospovidone, and MCC. The study found that MCC relies on a 'wicking' mechanism—it pulls water in, but doesn't swell much. Crospovidone also relies on wicking and shape recovery. Sodium starch glycolate, however, was identified as the material with the largest swelling capacity. For tablets packed with hydrophobic (water-repelling) ingredients—like many herbal sports supplements—the sheer mechanical force of Explotab's swelling is often the only way to guarantee the tablet breaks apart.

## Why Supplement Companies Use Proprietary Delivery Blends You will often see Explotab™ listed on the labels of advanced sports nutrition brands, such as Hi-Tech Pharmaceuticals, sometimes bundled into a 'Proprietary Blend with Explotab and Extend-Rx Technology.'

Why list an inactive excipient in a proprietary blend? 1. **Marketing:** It highlights that the company is using expensive, pharmaceutical-grade delivery systems rather than cheap manufacturing techniques. 2. **Biphasic Release:** By combining Explotab (which causes immediate, explosive rapid release) with Extend-Rx (which causes slow, sustained release), formulators can create a product that hits you quickly but lasts for hours. This is highly desirable in products like pre-workouts, fat burners, or pain management supplements (like Pain-Rx).

## Safety, Tolerability, and Excipient Status Sodium starch glycolate is universally recognized as safe. It is an FDA-approved excipient used in thousands of over-the-counter and prescription medications worldwide. Because it is an inactive polymer, it is not absorbed into the bloodstream; it simply does its mechanical job in the stomach and passes harmlessly through the digestive tract.

While it is derived from potato starch, the rigorous chemical processing and purification mean it is generally safe even for those with mild food sensitivities, and it is entirely gluten-free.

## Conclusion While it may not be the ingredient that builds muscle or burns fat, Explotab™ Technology is the unsung hero of high-quality supplement formulations. By ensuring that tightly compressed tablets disintegrate rapidly and completely, Explotab™ guarantees that you are actually absorbing the active ingredients you paid for, leading to faster onset times and better overall clinical outcomes.

📱 Questions about Proprietary blend with Explotab(TM) Technology?
Text us your goals. We'll match you to the right product and dose.
Real humans + SuppVault AI · Msg rates apply · Reply STOP
← Back to Supplement Periodic Table
Shop All 1 Products with Proprietary blend with Explotab(TM) Technology →