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Np
N-Phenethyl.

N-Phenethyl Dimethylamine Citrate

stimulant· Energy
D-Tier · Preliminary
Found in 14 products
Quick Answer:The clinical dose of N-Phenethyl Dimethylamine Citrate is 150-250mg (based on market data only; no clinical standard exists). N-Phenethyl Dimethylamine is a structural analogue of Phenethylamine (PEA), a naturally occurring neuromodulator.Found in 14 products on SuppVault.
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Products Containing N-Phenethyl Dimethylamine Citrate
14 products contain N-Phenethyl Dimethylamine Citrate.
Shop All 14 Products with N-Phenethyl Dimethylamine Citrate →
Mechanism of Action

N-Phenethyl Dimethylamine Citrate is a synthetic compound belonging to the phenethylamine class of stimulants. Its mechanism of action, while not confirmed through human clinical trials, is inferred from its chemical structure and its relationship to endogenous and supplemental phenethylamines (PEAs).

PEA Backbone and Receptor Interaction

The core of the molecule is the phenethylamine 'backbone'. This structure is common to many neurotransmitters (like dopamine and norepinephrine) and stimulants (like amphetamine). This backbone allows the molecule to interact with trace amine-associated receptors (TAARs), particularly TAAR1, and potentially modulate the release and reuptake of monoamine neurotransmitters. By mimicking endogenous neurotransmitters, it can trigger a signaling cascade that results in the release of dopamine and norepinephrine from presynaptic vesicles into the synapse, leading to increased neuronal firing and the subjective feelings of stimulation, focus, and euphoria.

Protection from Monoamine Oxidase (MAO) Degradation

Standard, unsubstituted Phenethylamine (PEA) is a very poor oral supplement on its own because it is a prime substrate for the enzyme Monoamine Oxidase-B (MAO-B) (EC 1.4.3.4), which is highly concentrated in the gut and liver. This first-pass metabolism rapidly deaminates PEA, rendering it inactive, typically within 5-10 minutes of ingestion. The defining feature of N-Phenethyl Dimethylamine is the presence of two methyl groups attached to the terminal nitrogen of the ethylamine side chain (N,N-dimethyl). This structural modification is hypothesized to provide steric hindrance, effectively 'shielding' the amine group from the active site of the MAO enzyme. This resistance to enzymatic degradation allows a greater concentration of the compound to pass into systemic circulation, cross the blood-brain barrier, and exert its effects on the central nervous system for a significantly longer duration than standard PEA.

Pharmacokinetics

The provided sources contain no information on the pharmacokinetics of N-Phenethyl Dimethylamine Citrate in humans. Key parameters such as oral bioavailability, time to maximum plasma concentration (Tmax), volume of distribution, and elimination half-life (t1/2) have not been clinically determined. The duration of its effects is anecdotally reported to be longer than PEA but shorter than more potent, restricted stimulants.

Works Best With
Caffeine
Caffeine acts as a central nervous system stimulant primarily through adenosine receptor antagonism. This provides a complementary but distinct pathway for increasing alertness and energy, potentially creating a synergistic effect with the dopamine-releasing properties of N-Phenethyl Dimethylamine.
Questions About N-Phenethyl Dimethylamine Citrate
What is N-Phenethyl Dimethylamine Citrate? +
N-Phenethyl Dimethylamine Citrate, also known as Eria Jarensis Extract, is a stimulant ingredient used in pre-workout and fat burner supplements. It is a derivative of Phenethylamine (PEA) and is known for producing a strong euphoric or 'feel-good' effect alongside increased energy and focus. It rose in popularity as a replacement for other potent stimulants that were removed from the market.
How does N-Phenethyl Dimethylamine work? +
Its proposed mechanism involves increasing levels of neurotransmitters like dopamine and norepinephrine in the brain. Unlike standard PEA, which is broken down very quickly by the MAO enzyme, N-Phenethyl Dimethylamine has two methyl groups that are thought to protect it from this rapid degradation. This allows it to remain active longer, resulting in a more sustained mood-enhancing and stimulant effect.
What are the main benefits of taking Eria Jarensis? +
Based on anecdotal reports, the primary benefits are a significant mood boost, a feeling of euphoria, increased energy, and sharper mental focus. It is used to make workouts feel more enjoyable and to provide the motivation to train intensely. There are no clinical studies to validate these benefits.
What is the recommended dosage for N-Phenethyl Dimethylamine? +
There is no clinically recommended dosage. Based on a survey of products on the market, a typical dose ranges from 150mg to 250mg. Some products contain as little as 100mg or as much as 500mg. It is always best to start with a lower dose to assess your individual tolerance.
When is the best time to take it? +
The best time to take N-Phenethyl Dimethylamine is about 20-30 minutes before a workout or any activity requiring a boost in energy and focus. Due to its potent stimulant effects, you should avoid taking it within 6-8 hours of bedtime to prevent it from interfering with your sleep.
What are the potential side effects? +
Since there is no safety data, potential side effects are based on other stimulants and user reports. These may include increased heart rate, elevated blood pressure, jitteriness, anxiety, and a post-use 'crash' in energy and mood. The long-term side effects are unknown.
Is N-Phenethyl Dimethylamine safe? +
The safety of N-Phenethyl Dimethylamine has not been established through clinical research. It is a potent stimulant that exists in a regulatory gray area. Individuals with pre-existing health conditions, particularly cardiovascular or psychiatric, should avoid it. Always consult with a healthcare professional before using any strong stimulant.
Is Eria Jarensis legal? +
The legal status of N-Phenethyl Dimethylamine is complex and can be considered a regulatory gray area. While not explicitly banned by name in some regions, it falls into a class of compounds that regulatory bodies like the FDA have scrutinized. Its status as a legitimate dietary ingredient is questionable.
Do I need to cycle N-Phenethyl Dimethylamine? +
Yes, it is highly recommended to cycle any strong stimulant. Continuous daily use can lead to tolerance, where you need more of the ingredient to feel the same effect, and potential dependency. A common cycling strategy is to use it for 4-8 weeks followed by a 2-4 week break.
Can I stack Eria Jarensis with other supplements? +
Yes, it is almost always stacked with other ingredients in pre-workout formulas. The most common ingredient to stack it with is caffeine for a synergistic energy boost. Be extremely cautious when combining it with other stimulants to avoid over-stimulation and negative side effects.
Who should not take N-Phenethyl Dimethylamine? +
Individuals who are pregnant or nursing, under 18, have heart conditions, high blood pressure, anxiety disorders, or are sensitive to stimulants should not take this ingredient. Additionally, athletes subject to WADA or other anti-doping tests should avoid it, as its metabolites may not be permissible.
Is there a branded version of N-Phenethyl Dimethylamine? +
Yes, the PricePlow source mentions a trademarked version called NeuroPEA™ from SYNMR Biotechnology. Branded ingredients often claim a specific purity or standardization, such as an 80% extract in the case of NeuroPEA™, which may offer more consistent dosing.
Does N-Phenethyl Dimethylamine require a loading phase? +
No, a loading phase is not necessary. N-Phenethyl Dimethylamine is a fast-acting stimulant, and its effects are felt shortly after a single dose. It does not need to accumulate in your system over time to be effective.
Are there any medication interactions I should be aware of? +
Yes, there is a high risk of serious interactions. You should never take this ingredient if you are on MAOIs (Monoamine Oxidase Inhibitors), SSRIs (Selective Serotonin Reuptake Inhibitors), or any other antidepressant or psychiatric medication. Combining them could lead to dangerous conditions like hypertensive crisis or serotonin syndrome.
Can I get N-Phenethyl Dimethylamine from food? +
No, N-Phenethyl Dimethylamine is not found in common foods. It is purported to be an alkaloid found in the plant species Eria Jarensis, but for supplement purposes, it is obtained through extraction or synthesis and is not part of a normal diet.
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