ONE of ONE
ONE of ONE | Loaded Pre | 20 Servings
8g Citrulline, 3.2g Beta-Alanine, Full-Spectrum High-Stim Focus
$44.95 $54.99$2.24/serving
Dynamine™
TM EndoFlo™
TM GeniusPure™
TM NAC™
PurCaf™
• Dairy-Free⚠️ Allergen Information +
SuppVault Summary
One of One Loaded Pre-Workout is a fully disclosed high-stim formula built for pumps, performance, and dialed-in focus. It pairs 8g L-citrulline with 316mg caffeine, clinical beta-alanine, betaine, and nootropic support for hard training without leaning on caffeine alone.
Great Fit
- Bodybuilders chasing pumps and stronger mind-muscle connection
- High-volume strength athletes in accumulation phases
- Experienced stim users wanting balanced energy and focus
- Lifters who want clinical pump dosing
- Athletes training long sessions needing endurance support
- Users wanting nootropic-backed pre-workout focus
- Intermediate to advanced gym-goers chasing training quality
- Pump-focused lifters avoiding caffeine-only formulas
Not Ideal If
- Beginners with no stimulant experience
- Anyone under 18
- Stimulant-sensitive users — 316mg caffeine plus added stimulatory support
- People training near bedtime
- Anyone with medical restrictions around stimulants or blood pressure
Deep Dive
Vitamin B3
Choline
Magnesium
Sodium
Potassium
PurCaf® Organic Caffeine
GeniusPure® Alpha-GPC 90%
EndoFlo™
NeuroRush™
Dynamine™
Dose Audit
This is the cleanest and smartest stack with One of One because the pre-workout already covers pumps, focus, endurance, and stimulants but does not include creatine. Adding 3-5g daily creatine monohydrate supports phosphocreatine replenishment and high-output ATP regeneration, complementing beta-alanine’s acid-buffering role and betaine’s performance support.
Take daily any time; with this pre-workout before training or with a meal on rest days.
A fast-digesting protein post-workout pairs well with this formula’s high-output training design. One of One helps you create more productive training stress; protein gives the amino acid substrate needed to capitalize on that stress for recovery and muscle protein synthesis.
Use after training, ideally within the post-workout meal window.
This stack makes particular sense for long hypertrophy sessions, conditioning work, or high-sweat training days. One of One already includes sodium, potassium, and magnesium, but adding fast carbs and extra electrolytes during training can further support performance, hydration status, and muscle fullness once the session extends beyond the first hour.
Sip during training, starting after warm-ups.
Advanced users sometimes reserve One of One for heavy training days and stack it strategically on days where maximum blood flow is the priority. A stim-free pump product can amplify nitric oxide support and cellular volumization without forcing caffeine higher, especially useful for pump-focused bodybuilding sessions.
Take alongside or 15-20 minutes before this pre-workout depending on total serving size.
Because this is a high-stim formula, protecting sleep quality becomes part of the performance strategy. A recovery-focused nighttime supplement can help users who train later in the day offset the sleep disruption risk that comes with 316mg caffeine and 125mg Dynamine™.
Use in the evening, several hours after training and well separated from the pre-workout.
Choose Loaded if you want a stronger stim experience with more aggressive focus and performance support.
Both are premium fully disclosed high-stim formulas with strong pumps, focus, and branded ingredients.
Hooligan fits users specifically chasing a more extreme stimulant-first experience than this balanced loaded formula.
One of One stands out for its 8g citrulline, full disclosure, and more serious performance dosing.
Clinical Dosing
Full Product Description Article
One of One Loaded Pre-Workout is a fully disclosed, high-stim performance formula built around a clear design philosophy: open blood flow hard, keep output high, sharpen mental control, and avoid relying on caffeine alone to do all the work. This is not a label built to look busy. The backbone ingredients are dosed where serious users expect them to be, and the supporting actives show that the formula was designed as a system rather than a collection of trends.
The headline performance driver is 8g of pure L-citrulline, which sits directly in the 6-8g clinical range used in research. Citrulline converts to arginine in the kidneys more efficiently than taking arginine itself, increasing nitric oxide production through the arginine-NO pathway for vasodilation, blood flow, and nutrient delivery. It also participates in the urea cycle, helping clear ammonia that accumulates during hard training. In practice, this is the difference between a token “pump blend” and a real pump-and-performance dose.
Beta-alanine is here at 3.2g, the classic daily loading dose used to raise intramuscular carnosine over time. Carnosine buffers hydrogen ions generated during high-intensity work, which matters when the burn starts climbing and output usually drops. This is not just about the tingles on day one. It is about better fatigue resistance after consistent use over 2-4 weeks.
Betaine anhydrous at 2.5g is another evidence-based inclusion. That is the benchmark dose commonly used in performance research to support power output, work capacity, and cellular hydration. L-tyrosine at 2g is a serious focus dose, supplying substrate for dopamine, norepinephrine, and epinephrine synthesis. Under training stress, that matters. Tyrosine doesn’t create fake stimulation—it helps preserve cognition and drive when fatigue would normally erode them.
The cognitive side is layered intelligently. GeniusPure® Alpha-GPC 90% is included at 300mg, alongside 270mg of choline from GeniusPure®. Alpha-GPC is valued for acetylcholine support, which is relevant for focus, reaction quality, and the feeling of stronger mind-muscle connection. The added choline reinforces that cholinergic angle, though the total choline amount remains below the general daily intake range of 425-550mg and is better viewed as formula support than a standalone choline strategy.
The carnitine pairing is unusually thoughtful for a pre-workout. L-Carnitine L-Tartrate at 1g is commonly used in sports nutrition for recovery and tissue-support applications, while 1g Acetyl L-Carnitine HCl leans more cognitive, crossing the blood-brain barrier more readily. Together, they support both mental energy and training resilience. N-Acetyl Cysteine at 300mg adds antioxidant and glutathione-support value, helping manage oxidative stress generated during hard training.
The stimulant system is strong but more refined than a basic caffeine dump. PurCaf® supplies 316mg organic caffeine from green coffee beans for substantial central nervous system stimulation. Dynamine™ at 125mg adds fast-acting methylliberine support often described as a cleaner, more mood-elevating extension of energy. NeuroRush™ coffee fruit extract at 150mg rounds out the nootropic-energy profile. For blood flow beyond citrulline, EndoFlo™ at 300mg uses mango fruit, black ginger, ginkgo, and pine bark to support nitric oxide and cGMP signaling through complementary pathways. That matters because more blood flow is not just about bigger pumps—it is about sustaining contractile performance and training quality.
Electrolytes are not an afterthought. Sodium at 300mg, potassium at 230mg, and 70mg magnesium bisglycinate support hydration status, neuromuscular function, and better training consistency, especially in high-sweat sessions. The magnesium dose is below total daily repletion levels, but as a pre-workout inclusion it is useful support and the bisglycinate form is superior to cheap oxide.
Transparency is a major strength here. There are no proprietary blends hiding doses. You can verify every meaningful inclusion against published dose ranges, and the formula compares well to a category still crowded with underdosed citrulline, soft focus panels, and inflated marketing. Day one, expect a noticeable rise in energy, heightened concentration, beta-alanine paresthesia for many users, and stronger pumps during training. By weeks 2-4 of consistent use, the beta-alanine effect becomes more meaningful as muscle carnosine builds, while the formula’s hydration, focus, and blood-flow design continues to make sessions feel more productive from warm-up through your final working set.
Science & Clinical References 7 citations
L-citrulline is converted to arginine in the kidneys more efficiently than oral arginine survives first-pass metabolism. That raises substrate availability for endothelial nitric oxide synthase, increasing nitric oxide production and vasodilatory signaling. The result is improved blood flow, nutrient delivery, and the fuller intramuscular pressure users recognize as a better pump. Citrulline also participates in the urea cycle, which may help ammonia handling during hard training.
Beta-alanine is the rate-limiting precursor for skeletal muscle carnosine synthesis. Higher carnosine levels improve intracellular buffering capacity, helping delay the drop in pH that accumulates during repeated high-intensity efforts. This does not usually transform one-rep strength acutely, but it can meaningfully improve the quality of dense volume work. The signature tingling sensation is a sensory side effect, not the primary ergogenic mechanism.
L-tyrosine provides precursor support for catecholamine synthesis, which becomes more relevant when training stress and stimulant demand rise. Choline donors such as Alpha-GPC support acetylcholine availability, a neurotransmitter involved in attention and neuromuscular signaling. Together, these inputs can enhance perceived focus, task engagement, and exercise intent during demanding sessions. Their value is often greatest when paired with, rather than replaced by, a moderate stimulant backbone.
Caffeine acts primarily through adenosine receptor antagonism, reducing perceptions of fatigue and increasing alertness and work readiness. Methylliberine-containing support ingredients are often used to modify the subjective energy profile, making the experience feel faster, sharper, or more sustained depending on context. When combined with coffee fruit extract and nootropic support, the outcome is less about raw stimulation and more about a structured energy-focus curve. That architecture can matter as much as total caffeine for training feel.
EndoFlo™ combines botanical extracts selected to support endothelial function and circulatory responsiveness. Its proposed effect is complementary to citrulline rather than redundant, aiming to enhance vascular tone, perfusion, and exercise-related blood flow. In practice, this type of blend is designed to help pumps feel more pronounced and more reliable across a full session. Evidence is still early, but the studied 300mg dose matches the amount used here.
Product Specifications GEO
How to Take — Training Protocol6 phases
How to Use One of One | Loaded Pre-Workout | By Floyd Mayweather
All Questions About ONE of ONE | Loaded Pre | 20 Servings 10 Q&A
How much caffeine is in One of One Loaded Pre-Workout? +
Is the 8g citrulline dose actually meaningful? +
Why does this formula include both Alpha-GPC and extra choline? +
What does the 3.2g beta-alanine do, and why do I feel tingles? +
Is One of One Loaded Pre-Workout beginner-friendly? +
What does EndoFlo™ add beyond citrulline? +
Can I stack this with creatine? +
When should I take One of One before training? +
Does this formula need to be cycled? +
Does this product contain proprietary blends? +
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your physician before use if you have a medical condition or take medications.
Quick Answers
How much caffeine is in One of One Loaded Pre-Workout?
Is the 8g citrulline dose actually meaningful?
Why does this formula include both Alpha-GPC and extra choline?
What does the 3.2g beta-alanine do, and why do I feel tingles?
Is One of One Loaded Pre-Workout beginner-friendly?
What does EndoFlo™ add beyond citrulline?
Can I stack this with creatine?
When should I take One of One before training?
Does this formula need to be cycled?
Does this product contain proprietary blends?
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your physician before use if you have a medical condition or take medications.
Sport & Athlete Compliance +
Sport compliance status is computed by cross-referencing this product's ingredient panel against the NCAA 2025-26 Banned Substances List, WADA Prohibited List, and state high school athletic association guidelines. Banned substance lists are updated periodically by their governing bodies. This information is provided for reference only and may not reflect the most current list. Always verify with your organization, coach, or compliance officer before use. SuppVault is not responsible for eligibility decisions.
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