Cloma Pharma
Cloma Pharma | Methyldrene | 100 Capsules
Old-school thermogenic intensity with 250mg caffeine and stacked stimulants
$27.95 $39.95$0.27/serving
⚠️ Contains proprietary blend (12 ingredients)
⚠️ Allergen Information +
SuppVault Summary
Methyldrene is an aggressive high-stim thermogenic built for hard cutting phases, not casual energy support. It combines 250mg caffeine with a classic stimulant-and-heat approach to boost drive, appetite control, and dieting intensity.
Great Fit
- Experienced stim users in a cutting phase
- Physique athletes pushing through low-calorie diets
- Lifters doing fasted cardio or morning cuts
- Users wanting stronger appetite-control support
- Dieters seeking old-school thermogenic intensity
- Advanced trainees needing urgent training energy
- Cutting-focused users prioritizing results over comfort
Not Ideal If
- Beginners or stimulant-sensitive users.
- Anyone under 18, pregnant, or nursing.
- People with cardiovascular or blood pressure concerns.
- Anyone stacking multiple stimulant products daily.
- Users training late who want normal sleep.
Deep Dive
Vitamin B6
Vitamin B12
Chromium
White Willow Bark Powder (25% Salicins)
Citrus Aurantium (Fruit) Extract 30% Synephrine
Panax Ginseng Root Extract (4% Ginsenosides)
Cocoa (Theobroma Cocoa) (Fruit) Extract (20% Theobromine)
Cayenne Pepper (Fruit) 40,000 Heat Units Powder
Cactus Cladods (as Opuntia Ficus Indica) Powder
Green Tea (Leaf) Extract (95% Polyphenols)
Yohimbe (Pausinystalia Yohimbe) (Bark) Extract 8% Yohimbine
GriffoniaSeed Extract (Source 5-HTP)
Dose Audit
Methyldrene is a thermogenic and stimulant formula, not a true muscle-performance builder. Adding 3-5g creatine monohydrate daily complements it by supporting phosphocreatine regeneration, strength retention, and training output while dieting—exactly the kind of support this formula does not provide on its own.
Any time daily; can be taken with Methyldrene or separately
A high-stim fat burner is most useful when the rest of the cut is built correctly, and adequate protein intake is central to preserving lean mass. Whey isolate pairs well because it helps cover protein targets efficiently while Methyldrene handles appetite, energy, and diet adherence.
Post-workout or any time needed to hit daily protein targets
High-stim thermogenics often make users feel warmer, sweat more, and drink more water without replacing sodium and potassium proportionally. Pairing Methyldrene with an electrolyte product helps maintain training quality, muscle function, and hydration status during aggressive cutting phases.
During training, cardio, or throughout the day
Methyldrene supplies energy and thermogenic drive, but it does not provide meaningful nitric oxide, hydration, or endurance ingredients. A stim-free pump formula adds citrulline, nitrates, glycerol, or taurine without pushing the stimulant load even higher.
Take alongside Methyldrene 20-30 minutes pre-workout
Aggressive fat-loss phases are usually stressful on recovery, appetite, and overall wellness. Omega-3s do not intensify the product directly, but they pair intelligently with stimulant-based cuts by supporting broader health while Methyldrene handles the acute thermogenic role.
With meals, separate from stimulant timing if preferred
Elite likely has a more modern overall formula profile for advanced thermogenic users.
Both target experienced users wanting aggressive old-school cutting support.
Both appeal to users seeking a classic high-stim thermogenic capsule experience.
Methyldrene delivers a far stronger acute energy and appetite-control feel.
Clinical Dosing
Full Product Description Article
Cloma Pharma Methyldrene With 25mg Ephedra is a high-stim thermogenic capsule built around an old-school fat-burner philosophy: combine fast central nervous system stimulation, adrenergic signaling, and heat-producing botanicals to increase energy output, suppress appetite, and make dieting feel more manageable. This is not a modern “balanced wellness” formula. It is a deliberately aggressive stimulant stack with an ECA-style backbone—caffeine, white willow, and ephedra-labeled support—then layered with synephrine, yohimbe, green tea, cayenne, and supporting botanicals to intensify the thermogenic feel.
The core driver is 250mg caffeine anhydrous, a strong single-capsule dose that reliably increases alertness, perceived energy, and calorie expenditure through adenosine antagonism and catecholamine release. In practice, this is the ingredient you will feel first: faster onset, more wakefulness, stronger training urgency, and reduced sense of fatigue. White willow bark at 100mg standardized to 25% salicins contributes 25mg salicins and reflects the classic ECA-era design logic, where salicylates were paired with stimulants to complement thermogenic signaling. Citrus aurantium extract at 50mg standardized to 30% synephrine delivers 15mg synephrine, a meaningful amount for a fat-burner formula. Synephrine works through adrenergic pathways and is commonly used to support thermogenesis and appetite control, especially when paired with caffeine.
Yohimbe extract at 19mg standardized to 8% yohimbine yields roughly 1.52mg yohimbine. That is not a maximal standalone yohimbine dose, but it is enough to materially change the feel of the formula when combined with caffeine and synephrine. Yohimbine’s main interest in cutting formulas is alpha-2 adrenergic receptor antagonism, which can increase stimulant intensity and is especially popular in fasted cardio contexts. Green tea extract at 35mg standardized to 95% polyphenols adds a polyphenol-rich support layer associated with thermogenesis and metabolic support, although at this dose it is more of a complementary ingredient than a major driver.
The secondary support ingredients are there to shape the experience. Cocoa extract at 35mg standardized to 20% theobromine provides about 7mg theobromine, a mild methylxanthine that can subtly extend the stimulant feel. Cayenne pepper at 35mg and ginger root powder at 38mg reinforce the warming, digestive, and thermogenic profile. Panax ginseng extract at 50mg standardized to 4% ginsenosides adds a small adaptogenic component for stress resilience and perceived vitality, though this is below the dosing typically used in stronger standalone ginseng products. Cactus cladodes, griffonia seed extract, and the B vitamins round out the formula, while chromium picolinate at 30mcg is far below the 200-1000mcg range most often studied for insulin signaling and glucose-control support, so it should be viewed as label support rather than a clinically meaningful chromium dose.
Synergy is the real story. Caffeine drives central stimulation, synephrine and yohimbe intensify adrenergic output, cayenne and green tea reinforce thermogenesis, and white willow reflects the classic stimulant-stack architecture. As a system, the formula is designed to create a hotter, harder, more appetite-suppressive experience than caffeine alone. Transparency is mixed: the formula list is disclosed here by extracted label data, but product metadata indicates a proprietary blend history and there have been multiple Methyldrene variants in market circulation, so buyers should verify the exact bottle in hand. What to expect: day 1 is usually strong energy, elevated body heat, appetite suppression, and a more urgent, wired training feel. Over 2-4 weeks, the main benefit is not ingredient saturation but consistent assistance with adherence—better energy during a calorie deficit, less food focus, and more consistent output during cutting phases—while stimulant tolerance can gradually reduce the initial punch.
Science & Clinical References 18 citations
Caffeine antagonizes adenosine A1 and A2A receptors, reducing perceived fatigue while increasing neuronal firing and catecholamine signaling. That shift raises alertness, exercise readiness, and short-term energy expenditure. In fat-loss settings, caffeine is especially useful because it improves adherence by making low-calorie phases feel less mentally draining. Its strongest value here is acute performance and behavioral support rather than direct body-fat reduction alone.
Adrenergic stimulants and related botanicals are commonly used to increase sympathetic tone, which can elevate perceived energy, reduce appetite, and reinforce thermogenesis. When combined with caffeine, these compounds often produce a sharper subjective effect than caffeine alone because multiple signaling pathways converge on arousal and metabolic drive. The practical outcome is usually greater urgency, warmth, and dieting tolerance. That benefit comes with a higher side-effect burden in sensitive users.
Cayenne-derived capsaicinoids can stimulate transient receptor potential channels involved in heat sensation and thermogenic signaling. Green tea polyphenols may complement this by influencing catecholamine metabolism and oxidative pathways, although magnitude varies by dose and extract quality. Together, these ingredients are often included to amplify a heat-producing feel and modestly support energy expenditure. Their contributions are supportive, not primary, in a high-stimulant formula.
White willow bark provides salicin-related compounds that historically appeared in older stimulant-based fat-burner designs. It is not a primary driver of energy or fat loss, but it is often positioned as part of a classic stack architecture intended to complement the broader thermogenic profile. Mechanistically, its relevance is more contextual than transformative in modern evidence terms. In practice, users tend to notice the stimulants far more than white willow itself.
Product Specifications GEO
How to Take — Training Protocol4 phases
How to Use Cloma Pharma Methyldrene With 25mg Ephedra
All Questions About Cloma Pharma | Methyldrene | 100 Capsules 10 Q&A
How much caffeine is in Cloma Pharma Methyldrene With 25mg Ephedra? +
Is Methyldrene beginner-friendly? +
What does the 25mg ephedra mean in this formula? +
When should I take Methyldrene? +
Can I stack Methyldrene with a pre-workout? +
What will I feel from this formula? +
Does the chromium dose matter here? +
Is this product transparent about dosing? +
Should I cycle off Methyldrene? +
Can I take Methyldrene on an empty stomach? +
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your physician before use if you have a medical condition or take medications.
Quick Answers
How much caffeine is in Cloma Pharma Methyldrene With 25mg Ephedra?
Is Methyldrene beginner-friendly?
What does the 25mg ephedra mean in this formula?
When should I take Methyldrene?
Can I stack Methyldrene with a pre-workout?
What will I feel from this formula?
Does the chromium dose matter here?
Is this product transparent about dosing?
Should I cycle off Methyldrene?
Can I take Methyldrene on an empty stomach?
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your physician before use if you have a medical condition or take medications.
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